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Target intelligence / Profile preview
Cell division cycle-associated 7-like protein (CDCA7L)
- Target
- CDCA7L
- Molecular classification
- Transcription factor, Protein coding gene
01
Overview
Cell division cycle-associated 7-like protein (CDCA7L) acts predominantly as a transcriptional regulator and repressor, notably inhibiting monoamine oxidase A (MAOA) gene expression by binding to its promoter[2][8]. CDCA7L supports cell cycle progression and cell proliferation and has a documented role in MYC-driven oncogenesis, particularly in medulloblastoma[3][8]. It is also involved in apoptotic signaling, with suggested regulatory links to genes and proteins such as CASP3/caspase-3, CCND1/cyclin D1, and E2F1[3]. Its molecular functions and disease associations reflect roles in cancer biology, cell differentiation, and potentially neurological disorders; however, no approved drugs currently target this protein, and its utility as a clinical biomarker or direct safety risks remain undocumented in available translational resources[3][6][8].
- Other names
- JPO2R1RAM2HR1Protein JPO2Transcription factor RAM2DKFZp762L0311GC07M021714
02
Biological functions
Transcriptional regulation (repressor of monoamine oxidase A (MAOA))Positive regulation of cell population proliferationCell cycle regulationApoptotic signaling pathwaysPossibly cell differentiation
03
Disease associations
Cancer (notably medulloblastoma via MYC-mediated transformation)Ciliary dyskinesia, primarySudden infant death syndrome (SIDS) susceptibility pathwayPossible involvement in neurological or developmental disorders (based on broad protein atlas and mouse model disease phenotypes)
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