Target intelligence / Profile preview

Cell Division Cycle Associated Protein 1 (CDCA1)

Target: CDCA1
Molecular classification: Protein, Kinetochore protein, Cancer-testis antigen

Overview

Cell Division Cycle Associated Protein 1 (CDCA1), also known as NUF2, is a component of the NDC80 complex essential for kinetochore-microtubule attachment and chromosome segregation during mitosis. It is overexpressed in various cancers, including colorectal cancer, lung cancer, oral cavity carcinoma, and melanoma, with limited expression in normal tissues, classifying it as a cancer-testis antigen. Elevated CDCA1 levels are associated with poor prognosis and increased tumor growth/survival. It is a potential therapeutic target for molecular-targeted therapies or peptide vaccine immunotherapy.

Other names: NUF2Kinetochore protein Nuf2

Mechanism of action

siRNA-mediated knockdown impairs proliferation/survival of cancer cells, CTL-mediated tumor cell killing

Biological functions

Kinetochore-microtubule attachmentChromosome segregationCell cycleCell proliferationCell survivalImmune response (CTL induction)

Disease associations

Cancer (Colorectal cancer, Lung cancer, Oral cavity carcinoma, Melanoma)Tumor growth/survival

Safety considerations

Potential for off-target effects with siRNA or other molecular-targeted therapies.Need for careful patient selection to ensure CDCA1 overexpression in tumors.

Biomarkers

CDCA1 expression levels (prognostic in oral cavity carcinoma and melanoma)

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