Cell division cycle associated protein 4 (CDCA4)

Cell division cycle associated protein 4 is a nuclear protein that regulates cell cycle progression, mitotic spindle organization, and E2F-dependent transcription, impacting cellular proliferation and apoptosis[1][2][3]. It participates in chromosome segregation and may function as a midzone factor in mitosis[3]. CDCA4 is abnormally expressed in several cancers, including Wilms tumor, breast cancer, and ovarian cancer, where it drives tumor growth by activating the AKT/mTOR pathway and promoting cell proliferation, while inhibiting apoptosis[2][3]. Knockdown of CDCA4 reduces proliferation and increases apoptosis, suggesting its importance as a candidate therapeutic target and biomarker[2].

Other names

CDCA4HEPP (Hematopoietic progenitor protein)

Experimental: Inhibition of CDCA4 suppresses cell proliferation and promotes apoptosis by downregulating AKT/mTOR signaling. Downregulation affects cyclin D1, AKT, mTOR direct phosphorylation status.