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Cell division cycle protein 20 homolog (CDC20)
- Target
- CDC20
- Molecular classification
- Cell cycle regulator, E3 ubiquitin ligase cofactor
01
Overview
Cell division cycle protein 20 homolog (CDC20) is an essential regulator of cell division, primarily functioning to activate the anaphase promoting complex/cyclosome (APC/C). This activation leads to the degradation of securin and S/M-phase cyclins, enabling sister chromatid separation and mitotic exit. CDC20 plays a crucial role in microtubule-dependent processes like nuclear movement and chromosome separation. Overexpression of CDC20 has been implicated in various cancers, promoting cell proliferation, inhibiting apoptosis, and enhancing cell migration and invasion. It is considered a promising therapeutic target, and several medicines that inhibit CDC20 have been developed.
- Other names
- Cell division cycle protein 20CDC20 homologp55CDC
02
Mechanism of action
Inhibition of CDC20 function, leading to cell cycle arrest and apoptosis
03
Biological functions
Cell cycle regulationAPC/C activationSubstrate recognitionMicrotubule-dependent processesRegulation of anaphase
04
Disease associations
CancerOsteosarcoma
05
Safety considerations
Potential for off-target effects due to CDC20's role in normal cell divisionChemoresistance
06
Interacting drugs
Cisplatin
1 more in the full profile.
07
Biomarkers
CDC20 expression levels (potential biomarker for cancer treatment)
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