Cell division cycle protein 23 homolog (CDC23)

Cell division cycle protein 23 homolog (CDC23) is an essential subunit of the anaphase-promoting complex/cyclosome (APC/C), a large, multisubunit E3 ubiquitin ligase that controls progression through mitosis and G1 phase by catalyzing ubiquitin-mediated degradation of key regulators such as cyclin B1 and securin[2][3][4]. It contains tetratricopeptide repeat (TPR) domains important for protein–protein interactions within the complex. CDC23 is critical for orderly cell cycle transition, and its dysfunction causes cell cycle arrest, inhibits proliferation, and is linked to several cancers[1][3][4]. Recent studies indicate CDC23 may contribute to tumorigenesis and metastasis by regulating the epithelial-mesenchymal transition (EMT), and its expression is significantly higher in various cancer cell types, making it a potential novel therapeutic target[1][3][4].

Other names

Anaphase-promoting complex subunit 8APC8ANAPC8CUT23Cyclosome subunit 8

Inhibition or knockdown causes arrest in G2/M phase by blocking ubiquitin-mediated degradation of key cell cycle regulators (e.g., cyclin B1, securin)