Cell division cycle protein 27 homolog (CDC27)

Cell division cycle protein 27 homolog (CDC27) is an essential subunit of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that regulates cell cycle progression by targeting key cell cycle proteins such as cyclin B and securin for proteasomal degradation[3][4][5][1]. CDC27 contains tetratricopeptide repeat (TPR) domains, enabling interactions with mitotic checkpoint proteins (such as Mad2, BubR1, p55CDC) and recruitment of coactivators CDC20 and CDH1, both of which are crucial for proper timing of mitosis and G1 phase transition[2][3][5][6][1]. Dysregulation of CDC27 or APC/C complex function contributes to genomic instability and is associated with the development of cancer and related cell cycle disorders[6][5]. No approved therapeutics directly target CDC27/APC3; however, the APC/C complex is an emerging cancer drug target[6].

Other names

ANAPC3APC3CDC27HsD0S1430ED17S978EH-NUCHNUCNUC2cell division cycle 27anaphase-promoting complex subunit 3nuc2 homolog

Inhibition or modulation of APC/C complex activity (notably through targeting its E3 ligase function) Modulation of substrate ubiquitination and degradation (indirect, as APC/C is not yet a direct drug target)