Cell-extracellular matrix interface

The **cell–extracellular matrix (ECM) interface** is the specialized region where cells physically connect to the surrounding ECM via diverse cell-surface receptor families, most prominently the integrins[2][3][4][5][9]. This interface is a dynamic hub crucial for cell adhesion, bidirectional mechanical and biochemical signaling (mechanotransduction), migration, and tissue organization[7][8]. Integrins anchor the cell cytoskeleton to the ECM and, together with other receptors (such as syndecans and discoidin domain receptors), regulate pathways involved in proliferation, survival, differentiation, and movement[2][3][5]. Dysregulation at the cell–ECM interface is implicated in cancer metastasis, fibrosis, chronic inflammation, wound healing defects, and cardiovascular disease, largely through abnormal signal transduction and ECM remodeling[2][4][7]. While integrins and their associated adhesion complexes are frequent drug targets, the interface itself is not a single discrete molecule and should not be considered a canonical therapeutic target.

Other names

Cell–ECM interfaceCell–extracellular matrix junctionCell–matrix adhesion site