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Target intelligence / Profile preview
Cell-free DNA (cfDNA)
- Target
- cfDNA
- Molecular classification
- DNA fragment
01
Overview
Cell-free DNA (cfDNA) refers to extracellular fragments of DNA that are freely circulating in various body fluids. These fragments are typically double-stranded and range in size from about 120 to 220 base pairs. cfDNA can originate from both normal cellular processes and pathological conditions. It serves as an important biomarker for multiple clinical applications, including cancer diagnostics, prenatal testing, and transplantation monitoring.
- Other names
- Circulating free DNActDNA (circulating tumor DNA)cffDNA (cell-free fetal DNA)dd-cfDNA (donor-derived cell-free DNA)ccf mtDNA (cell-free mitochondrial DNA)
02
Biological functions
BiomarkerGenetic material released upon cell death
03
Disease associations
CancerPrenatal genetic disordersOrgan transplant rejectionTraumaSepsisInflammation-related diseasesMyocardial infarctionStrokeDiabetesSickle cell disease
04
Safety considerations
Variable concentration depending on physiological statePotential for false positives/negatives in prenatal screening
05
Biomarkers
Cancer detectionMonitoring treatment response in cancerPrenatal screening for chromosomal abnormalitiesTransplant rejection monitoringDisease progression monitoring
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