Cell-free RNA transcriptome (cfRNA transcriptome)

Cell-free RNA transcriptome refers to the complete set of RNA transcripts (including mRNA, non-coding RNA, mitochondrial RNA, etc.) freely circulating in body fluids such as blood plasma, outside of cells[1][2][3][5][6]. These RNA molecules originate from multiple tissues and cell types, entering circulation primarily via cell death (apoptosis or necrosis), secretion, or shedding of microvesicles and exosomes. The cfRNA pool is dynamic, rapidly reflecting physiological and pathological changes, and is highly tissue-specific. Because cfRNA carries gene expression signatures from multiple organs, its analysis provides a noninvasive means for monitoring health status, disease progression (especially cancer, fetal health, and organ injury), and underlying tissue pathology. While cfRNA offers extensive potential as a biomarker for diagnosis and prognosis, it is not itself a therapeutic target, but rather a source of molecular information about underlying cellular or tissue processes[1][2][3][5][6][7]. Specific notes regarding structure entries: - "Cell-free RNA transcriptome" is a *sample type/biocompartment/omic profile*, not a molecular target such as a protein, enzyme, or receptor. Therefore, is_target should be "false" and is_incorrect should be "true" (not a canonical drug target; potential confusion if listed as such). - No known drugs act by targeting cfRNA itself; rather, various diseases can be monitored by analyzing cfRNA signatures. - cfRNA is used as a *biomarker* source in liquid biopsies, not directly manipulated by drugs; mechanisms of action, drug interactions, and safety concerns relate to technical or interpretive limitations in cfRNA analysis, not to pharmacological intervention. - cfRNA analysis is gaining traction for noninvasive diagnostics, enabling molecular monitoring of cancer progression, organ injury, fetal development, and other conditions[1][2][3][5][6][7].

Other names

Cell-free RNA (cfRNA)circulating cell-free RNAplasma cfRNA