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Cell growth regulator with EF-hand domain protein 1 (CGREF1)
- Target
- CGREF1
- Molecular classification
- Other (Secreted calcium-binding protein), Cell adhesion molecule
01
Overview
Cell growth regulator with EF-hand domain protein 1 (CGREF1) is a calcium-binding, secreted protein containing two EF-hand domains that are both essential for its function[1][6]. It mediates cell-cell adhesion in a calcium-dependent manner and inhibits cellular proliferation in various cell lines, potentially acting as a negative regulator of cell population expansion[1][3][6]. CGREF1 appears to be digested extracellularly by unknown serine proteases, generating hydrophobic bioactive peptides[1]. While it is implicated in cellular growth control and intercellular adhesion, there is no current evidence for its use as a therapeutic target, disease biomarker, or drug interaction partner[1][2][3][6][7].
- Other names
- CGREF1Cell growth regulatory gene 11 proteinCGR11HydrophobestinCell growth regulator with EF hand domain protein 1cell growth regulatory gene 11 protein
02
Biological functions
Cell-cell adhesion (calcium-dependent)Negative regulation of cell proliferation
03
Disease associations
Other (no direct roles in specific diseases such as cancer, inflammation, or neurodegenerative disease reported)
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