Cell-matrix interaction (null)

Cell-matrix interaction" refers to the complex set of molecular processes through which cells interact with their surrounding extracellular matrix (ECM), a structure composed of proteins (e.g., collagen, fibronectin, laminin), glycoproteins, and polysaccharides[1][2][5][10]. These interactions are primarily mediated by specific cell-surface receptors—most notably integrins, but also discoidin domain receptors, CD44, RHAMM, and others—which transmit biochemical and mechanical signals across the cell membrane to regulate cellular functions such as adhesion, migration, differentiation, proliferation, and survival[2][5][6][7][3]. These processes are fundamental to tissue formation, maintenance, morphogenesis, and organ development, and have critical roles in both normal physiology and pathology, including cancer, fibrosis, and cardiovascular diseases[1][3][6][8]. "Cell-matrix interaction" itself is a process, not a discrete druggable target; therapeutic interventions usually focus on the individual molecular players involved in these interactions, such as specific ECM receptors or matrix components.

Other names

Cell-to-matrix interactionCell–extracellular matrix interaction

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