Cell-matrix interfaces

The cell-matrix interface encompasses the dynamic structural and functional regions where cells physically and chemically interact with the extracellular matrix (ECM)[1][3][5]. This interface involves matrix receptors such as integrins and associated adhesive proteins that connect the cell cytoskeleton to ECM proteins like collagen and fibronectin[1][5]. The interface enables cells to adhere, migrate, sense mechanical and biochemical signals, and direct structural and functional behaviors essential for development, tissue repair, and disease processes[2][3][4][6][7]. While not a single drug target, the molecules composing these interfaces—particularly integrins and adhesion complexes—are clinically relevant in conditions such as cancer metastasis, fibrosis, and vascular diseases[2][4][5][7]. The term “cell-matrix interface” is structurally and functionally descriptive, rather than denominating an individual molecule, and is best interpreted as referring to sites of interaction between cells and their ECM via receptor complexes (e.g., integrins), scaffolding proteins, and associated signaling pathways.

Other names

cell–extracellular matrix interfacecell–matrix junctioncell–ECM contact sitesfocal adhesion

Inhibition of integrin-ligand binding, blocking cell adhesion or migration; Modulation of matrix assembly or degradation (e.g., MMP inhibitors)