Target intelligence / Profile preview

Cell-mediated immunity (CMI)

Target: CMI
Molecular classification: Immune response mechanism

Overview

Cell-mediated immunity is an adaptive immune response that does not rely on antibodies but instead involves the activation of immune cells like T lymphocytes, macrophages, and NK cells. It is crucial for eliminating intracellular pathogens, destroying cancerous cells, and mediating delayed-type hypersensitivity reactions. The process involves antigen presentation via MHC molecules, activation of T cells, and subsequent killing of infected or abnormal cells through mechanisms like perforin/granzyme-induced apoptosis and cytokine secretion.

Mechanism of action

N/A

Biological functions

Elimination of intracellular pathogensDestruction of cancerous/transformed host cellsRegulation of immune responsesImmunological memory

Disease associations

InfectionCancerAutoimmunityTransplant rejection

Safety considerations

Immune-related adverse eventsCytokine release syndromeGraft-versus-host disease

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