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Cell-mediated immunity is a type of immune response that does not rely on antibodies but instead uses cells such as T lymphocytes (primarily cytotoxic CD8+ T cells and helper CD4+ T cells), macrophages, and natural killer cells to recognize and eliminate infected or abnormal cells[1][2][3][5]. Activation occurs when T cells recognize antigens presented by antigen-presenting cells on major histocompatibility complex (MHC) molecules, leading to a cascade of cytokine release and immune cell activation[1][2][3]. This mechanism is essential for defense against intracellular pathogens (such as viruses and some bacteria), cancer cells, and plays roles in transplant rejection and some autoimmune diseases[2][3]. Summary: "Cell-mediated immunity induction" is a descriptor for a complex immunological process and not a molecular target or receptor. Thus, it is not suitable as a canonical drug target entry[1][2][3][5].
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