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Cell Membrane (Cancer Cells) (N/A)
- Target
- N/A
- Molecular classification
- Lipid Bilayer, Lipid Raft, Protein Complex, Receptor Complex
01
Overview
The cell membrane of cancer cells exhibits unique structural and functional modifications compared to normal cells. It acts as a barrier, facilitates communication and transport, and plays critical roles in signaling, motility, invasion, metastasis, redox balance regulation, and drug resistance. Key alterations include increased cholesterol content, altered lipid composition, overexpression of specific receptors and transporters, and the formation of an acidic microenvironment. Therapeutic strategies exploit these differences to selectively target and kill cancer cells.
- Other names
- Plasma Membrane (Cancer Cells)
02
Mechanism of action
Targeting exposed PS/PE, Disrupting lipid rafts, Inhibiting V-type ATPases
03
Biological functions
Cell signalingCell motilityCell invasionMetastasisDrug resistanceRedox balance regulationCell death regulationTransport
04
Disease associations
Cancer
05
Safety considerations
Off-target effects due to membrane components also present in normal cellsDevelopment of resistance to membrane-targeting therapies
06
Interacting drugs
Resveratrol
1 more in the full profile.
07
Biomarkers
Phosphatidylserine (PS)Phosphatidylethanolamine (PE)Cholesterol levelsCeramide levelsVacuolar H(+)-ATPases
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