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The cell membrane osmotic gradient describes the difference in solute concentration between the inside and outside of a cell, across the selectively permeable plasma membrane. This gradient drives the passive movement of water (osmosis) to equalize solute concentrations, thereby regulating cell volume and maintaining cellular homeostasis. Disruption in the osmotic gradient can result in cellular dysfunction, including swelling, shrinkage, or lysis, particularly in pathological conditions or with improper fluid balance.
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