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Cell Membrane Proteins (Ocular)
- Molecular classification
- Aquaporin, Connexin, G protein-coupled receptor, Enzyme, Ion channel, Structural protein, Transporter
01
Overview
A diverse group of integral and peripheral membrane proteins found throughout ocular tissues including the cornea, lens, and retina. They function as water channels (aquaporins), gap junction components (connexins), light-sensitive receptors/transducers involved in vision (rhodopsin/photopsin/transducin/PDE6/CNG channels), accessory signaling regulators/chaperones. These proteins are critical for maintaining ocular homeostasis, transparency, and proper visual function.
02
Biological functions
Water transportSignal transductionIntercellular communicationMaintenance of cell structureIon transportPhototransduction
03
Disease associations
CataractBlindnessRetinal degenerationColor blindnessIntraocular pressure dysregulation
04
Safety considerations
Off-target effects due to wide tissue distributionPotential for drug-induced ocular toxicity
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