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Target intelligence / Profile preview
Cell membrane receptor for C-peptide
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
The cell membrane receptor for C-peptide is a putative GPCR that mediates the biological effects of C-peptide. While its exact molecular identity remains unknown, evidence supports its existence based on stereospecific binding, nanomolar affinity, and activation of downstream signaling pathways. Activation results in enhanced blood flow, improved nerve conduction velocity, increased Na+/K+-ATPase activity, and reduced oxidative stress and inflammation. It is considered a therapeutic target for diabetic complications.
- Other names
- C-peptide receptorC-peptide binding siteC-Peptide GPCR
02
Mechanism of action
GPCR activation leading to intracellular Ca2+-dependent pathways and downstream signaling cascades, including MAPK, PLCγ, PKC, eNOS and AMPKα activation.
03
Biological functions
Signal transductionVasodilationAnti-inflammationNeuroprotectionRegulation of Na+/K+-ATPase activityRegulation of eNOS activityRegulation of intracellular calciumRegulation of MAPK signaling pathwayRegulation of PLCγ signaling pathwayRegulation of PKC signaling pathwayRegulation of AMPKα signaling pathway
04
Disease associations
Diabetic neuropathyDiabetic nephropathyCardiovascular complications of diabetesEndothelial dysfunctionInflammation
05
Safety considerations
Target is not fully characterized, which presents challenges for drug development.Off-target effects due to unknown receptor structure.
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