Cell-Scaffold Interface

The cell-scaffold interface is the region where cultivated or native cells interact directly with an artificial or natural scaffold material, fundamental to tissue engineering. This interface governs the attachment, proliferation, differentiation, and function of cells on the scaffold, as well as the biocompatibility and integration with the host tissue. Successful design of the cell-scaffold interface requires control over scaffold properties such as surface chemistry, topography, porosity, stiffness, and degradation rate to modulate cellular behavior and optimize tissue regeneration outcomes. Alterations at this interface can result in inflammatory reactions, immune responses, and ultimately determine the success of tissue-engineered constructs[1][2][3][4][5][6][7].