Cell-surface extracellular matrix receptor (ECM receptor)

Cell-surface extracellular matrix (ECM) receptors are a diverse group of transmembrane proteins that mediate the attachment of cells to the surrounding extracellular environment and translate mechanical and chemical cues into intracellular signals. The most prominent members of this group are the integrins, but it also includes non-integrin receptors such as syndecans, discoidin domain receptors (DDRs), and CD44. These receptors play critical roles in maintaining tissue architecture, regulating cell survival, and directing migration during development and wound healing. In pathological states, dysregulation of ECM receptors is a hallmark of cancer progression, where they facilitate tumor cell invasion and metastasis, as well as fibrotic diseases characterized by excessive matrix deposition. Therapeutic strategies targeting these receptors often involve monoclonal antibodies or small molecules designed to block ligand binding or inhibit downstream signaling cascades.

Other names

Extracellular matrix receptorsECM-binding receptorsCell-matrix adhesion receptors

Antagonism of ligand binding (e.g., blocking fibrinogen or VCAM-1 binding), modulation of intracellular signaling pathways (outside-in signaling), and inhibition of cell-matrix adhesion.