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Target intelligence / Profile preview
Cell-Surface Glycan
- Molecular classification
- Glycoprotein, Glycolipid, Proteoglycan, Carbohydrate
01
Overview
Cell-surface glycans are complex carbohydrate structures covalently attached to proteins (glycoproteins), lipids (glycolipids), or proteoglycans on the exterior surface of cells. These molecules form a dense and dynamic layer known as the glycocalyx, which plays critical roles in cell-cell communication, signaling, adhesion, migration, immune response modulation, and disease progression. Alterations in cell-surface glycan structures are associated with cancer progression/metastasis, autoimmune diseases, and infectious diseases. Engineering or targeting specific glycans is an emerging therapeutic strategy.
- Other names
- GlycocalyxCell surface carbohydratesMembrane Glycans
02
Mechanism of action
Glycan engineering or targeting
03
Biological functions
Cell-cell communicationCell-matrix interactionsProtein folding/stabilityImmune response modulationDevelopmental processesSignal transductionCell adhesionCell migration
04
Disease associations
CancerAutoimmune diseasesInfectious diseasesInflammation
05
Safety considerations
Off-target effects due to glycan heterogeneityImmune responses to engineered glycans
06
Biomarkers
Sialic acid content (cancer)Specific glycan motifs
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