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Target intelligence / Profile preview
Cell surface transmembrane glycoprotein CD200 receptor (CD200R)
- Target
- CD200R
- Molecular classification
- Receptor, Immunoglobulin superfamily
01
Overview
CD200 receptor (CD200R), also known as OX2 receptor, is a cell surface transmembrane glycoprotein primarily expressed on myeloid lineage cells—including macrophages, dendritic cells, neutrophils, and mast cells—as well as some lymphoid populations such as CD4+ T cells. Its main ligand is CD200 (OX2), a widely distributed membrane glycoprotein. Engagement of CD200R by its ligand leads to potent inhibition of immune activation.
- Other names
- OX2 receptor
02
Mechanism of action
Engagement of CD200R by CD200 leads to phosphorylation at NPXY motifs which recruit DOK adaptor proteins, primarily DOK2, leading to downstream Ras/MAPK pathway inhibition and subsequent immune suppression.
03
Biological functions
Immune regulationInhibitory signalingMyeloid-derived immune response modulationBone homeostasis
04
Disease associations
Autoimmune diseasesAllergic disordersCancerBone disordersInflammation
05
Safety considerations
Tumor immune evasion through CD200R overexpressionPotential for pathogen hijacking of the CD200/CD200R pathway for immune evasion
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