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Cell Therapy
- Molecular classification
- Cells, Hematopoietic Stem Cells, Mesenchymal Stem Cells, Skeletal Muscle Stem Cells, Lymphocytes, T-cells, Dendritic Cells, Pancreatic Islet Cells
01
Overview
Cell therapy is a therapeutic approach in which viable cells are administered to a patient to achieve a medicinal effect, treating or preventing diseases by either replacing damaged tissue/cells or modulating the body's own repair mechanisms. Cells can be sourced from autologous or allogeneic sources and include various types such as hematopoietic stem cells, mesenchymal stem cells, and lymphocytes. The mechanism of action involves either engraftment and replacement of damaged tissue or paracrine/endocrine effects promoting self-healing. Applications span regenerative medicine, immunotherapy, hematologic conditions, and autoimmune diseases. Notable examples include CAR-T cell therapy, TCR-T cell therapy and hematopoietic stem cell transplantation. Safety concerns include immune rejection and off-target effects.
- Other names
- Cellular TherapyCell TransplantationCytotherapy
02
Mechanism of action
Engraftment and replacement of damaged tissue; Paracrine/Endocrine effects promoting self-healing.
03
Biological functions
Tissue RepairTissue RegenerationImmunomodulationCell ReplacementSecretion of CytokinesSecretion of ChemokinesSecretion of Growth FactorsAngiogenesisAnti-inflammation
04
Disease associations
Regenerative MedicineImmunotherapyHematologic ConditionsAutoimmune DiseasesInfectious DiseasesCancerSpinal Cord InjuriesBlood Cancers
05
Safety considerations
Immune rejection (for allogeneic cells)Off-target effects (for genetically modified cells)Tumorigenicity (for stem cells)Graft-versus-host disease (GVHD)
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