Cell wall and periplasmic proteins involved in ATP production (Helicobacter pylori)

This target group encompasses the specialized enzymes and proteins located within the cell wall and periplasmic space of Helicobacter pylori that are essential for generating the energy required for bacterial survival in the acidic gastric environment. Key components include the [NiFe]-hydrogenase, which oxidizes molecular hydrogen to feed electrons into the respiratory chain, and the urease enzyme system, which, while primarily cytoplasmic, is found in the periplasm where it neutralizes acid to maintain the proton motive force necessary for ATP synthase activity. These proteins are critical for the bacterium's unique bioenergetic strategy, allowing it to maintain a near-neutral internal pH and produce ATP via oxidative phosphorylation despite the extreme external acidity of the stomach. Because these enzymes are located outside the cytoplasm or are associated with the inner membrane facing the periplasm, they are accessible to specific inhibitors and are vital for the pathogen's colonization and persistence. Targeting these metabolic pathways represents a strategy to eradicate H. pylori by disrupting its energy supply and acid resistance mechanisms.

Other names

H. pylori respiratory chain proteinsPeriplasmic bioenergetic enzymesHelicobacter pylori ATP production machineryGastric colonization factors

Inhibition of cell wall synthesis (e.g., beta-lactams), inhibition of protein synthesis (e.g., macrolides), or disruption of metabolic enzymes and DNA (e.g., nitroimidazoles) to arrest energy production and cause bacterial cell death.