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Cell wall biosynthesis is the process by which bacteria construct their cell wall, primarily composed of peptidoglycan. This process involves multiple enzymatic steps, starting with precursor synthesis in the cytoplasm, followed by transport across the cell membrane, polymerization of glycan chains, and cross-linking of peptide side chains. It is essential for bacterial survival and a major target for antibiotics. Specific enzymes like glycosyltransferases, transpeptidases (PBPs), autolysins, and flippases are crucial for the process. Disrupting these steps leads to bacterial cell death.
Inhibition of peptidoglycan synthesis
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