Cellular and endosomal membranes

Cellular and endosomal membranes are complex lipid bilayers that define the boundaries of the cell and its internal compartments, serving as critical platforms for signal transduction and nutrient transport (Alberts et al., Molecular Biology of the Cell). They regulate the internal environment through processes like endocytosis, which is essential for the uptake of macromolecules and the regulation of surface receptors (Nature Reviews Molecular Cell Biology). While not a specific molecular target like a protein, these membranes are the site of action for several classes of drugs, including polyene antifungals like Amphotericin B that bind to membrane sterols to induce leakage (StatPearls). Additionally, endosomal membranes represent a significant barrier in the delivery of genetic medicines, where lipid nanoparticles must achieve endosomal escape to release their cargo into the cytosol (Nature Reviews Drug Discovery). Disruption of these membranes is also a primary mechanism used by certain antibiotics, such as Daptomycin, to kill bacterial pathogens by inducing rapid depolarization (PubMed). Understanding the physicochemical properties of these membranes is crucial for developing targeted therapies and improving drug delivery efficiency.

Other names

Plasma membraneLipid bilayerCytoplasmic membraneEndocytic vesiclesBiological membrane

Membrane permeabilization, pore formation, modulation of endosomal pH, and inhibition of viral fusion or uncoating.