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Cellular ATP-dependent enzyme

Molecular classification
Enzyme, ATPase, Family/families: P-loop NTPases, ABC ATPases, chromatin remodeling complexes (e.g., SWI/SNF, ISWI, CHD, INO80)
01

Overview

Cellular ATP-dependent enzymes are proteins that utilize the energy derived from ATP hydrolysis to perform essential cellular functions. The group includes molecular motors and remodelers (such as chromatin-remodeling complexes like SWI/SNF, ISWI, CHD, and INO80), transporters (like the ATP-binding cassette, or ABC transporter family), ATP-dependent proteases, and other molecular machines involved in nucleic acid metabolism, DNA repair, and protein homeostasis[2][3][4][5][7]. These enzymes are highly conserved across species and are critical to processes such as gene regulation, protein degradation, and transport of molecules across membranes. Due to their broad and essential roles in cell biology, the term lacks specificity and should be replaced by a precise enzyme name for structured annotation or therapeutic targeting.

Other names
ATPaseATP-dependent enzyme
02

Biological functions

Cellular energy transductionChromatin remodelingNucleic acid manipulationTransport (e.g., ABC transporters)Protein degradation (e.g., ATP-dependent proteases)DNA repairTranslation regulationMetabolic processes
03

Disease associations

CancerNeurodegenerative diseaseInfectionInflammationCardiovascular disease

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