Cellular DNA Double-Strand Break Induction (DSB Induction)

Cellular DNA double-strand break (DSB) induction refers to the creation of breaks in both strands of the DNA helix. These breaks can arise from exogenous sources like radiation and chemicals, or endogenously during DNA replication, meiosis, and immune system development. DSBs are highly cytotoxic and can lead to chromosomal instability, cell death, or tumorigenesis if not properly repaired. The DNA Damage Response (DDR) network detects and orchestrates repair through pathways like homologous recombination (HRR) and non-homologous end joining (NHEJ). Unrepaired or misrepaired DSBs can result in chromosomal rearrangements, mutations, and oncogenic translocations.

Other names

DNA Double-Strand BreaksDSBsDNA Damage Response (DDR)

Various mechanisms depending on the inducing agent, including direct DNA cleavage, generation of reactive oxygen species, and interference with DNA replication/repair.