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Cellular Membrane (CM)
- Target
- CM
- Molecular classification
- Lipid bilayer, Phospholipid, Cholesterol, Membrane protein, Receptor, Transporter, Enzyme, Adhesion molecule, Carbohydrate
01
Overview
Cellular membranes are thin biological barriers that surround every living cell, composed of a phospholipid bilayer with embedded proteins, cholesterol, and carbohydrates. They separate and protect the cell's interior, regulate transport, facilitate cell communication, and provide structural support. While the membrane itself is not a direct therapeutic target, its protein components (receptors, transporters, enzymes, etc.) are frequent drug targets.
- Other names
- Cell membranePlasma membrane
02
Mechanism of action
Varied, depending on the targeted membrane protein (e.g., receptor agonists/antagonists, channel blockers, enzyme inhibitors)
03
Biological functions
Barrier functionSelective permeabilitySignal transductionStructural supportCell-cell recognitionTransport
04
Disease associations
CancerInfectionNeurodegenerative diseaseCardiovascular diseaseOther
05
Safety considerations
Off-target effects due to membrane protein promiscuityDrug delivery challenges
06
Interacting drugs
Many drugs target membrane proteins
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