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The term "cellular and endosomal membranes" refers to the collection of **phospholipid bilayers** that make up the boundary of the cell (the plasma membrane) and the surrounding membranes of internal organelles, particularly endosomes. These membranes are essential for *compartmentalizing cellular processes*, allowing directed trafficking, protein and lipid sorting, import/export of materials, and degradation of internalized substances[1][2][3][4][6][7]. Whereas the **plasma membrane** regulates interactions between the cell and its environment, **endosomal membranes** are part of the endomembrane system that mediates internal sorting, signaling, and trafficking (e.g., via early endosomes, late endosomes, and lysosomes)[2][4][6]. These structures are not considered single molecular targets for drugs but play critical roles in cellular physiology and are studied in relation to disease when their function is disrupted.
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