Cellular metabolic pathway and nucleic acid synthesis

"Cellular metabolic pathway and nucleic acid synthesis" is not a single molecular target but a collection of interconnected biochemical networks responsible for energy production, macromolecule biosynthesis, and cellular homeostasis. In disease, especially cancer, these pathways are often reprogrammed to support proliferation and survival. Therapeutic strategies target specific enzymes or transporters within these pathways (e.g., antifolates, glutaminase inhibitors), but the broad category itself is not druggable as a single entity. Patient stratification and efficacy monitoring use biomarkers of pathway activity or metabolite levels. Due to the essential nature of core metabolism, targeting these pathways carries risks of toxicity and requires consideration of metabolic context and compensatory mechanisms[1][2][4].

Other names

Metabolic pathwayMetabolic reprogrammingMetabolic networkEnergy metabolismNucleotide biosynthesisNucleic acid metabolism

Inhibition of enzyme targets within metabolic pathways, Redirection of metabolic flux, Depletion of nucleotide precursors, Disruption of redox balance