Host metabolic pathways

Host metabolic pathways refer to the complex and interconnected series of biochemical reactions enabling the synthesis (anabolism) and degradation (catabolism) of biomolecules, supplying energy and building blocks required for cell survival, growth, communication, and adaptation. In the context of disease or drug development, "host metabolic pathways" is not a precise molecular target, but rather a category encompassing numerous enzymes, transporters, and metabolic actions within the host cell. These pathways are implicated in disease pathogenesis (e.g., cancer metabolism, infection where pathogens hijack host metabolism), therapeutic intervention, and the modulation of drug efficacy and toxicity. Because of their central role and diversity, targeting host metabolic pathways must be approached with caution to avoid unintended effects on normal physiology. In summary, "host metabolic pathways" is not a conventional, singular drug target, but a broad system comprising many distinct molecules and pathways relevant to health and disease. Therefore, it is not suitable for structured target-level annotations as required for individual receptors, enzymes, or proteins.

Other names

Metabolic pathways (host)Host metabolismCellular metabolic pathwaysEndogenous metabolic pathways

Enzyme inhibition or activation (e.g., acetyl-CoA carboxylase inhibitors); Modulation of metabolic flux (e.g., AMPK activators); Alteration of substrate availability (e.g., glucose analogs); Targeting host metabolic dependencies of pathogens (host-directed therapy).