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Cellular Mitotic Machinery
- Molecular classification
- Protein complex, Microtubule-based structure, Motor proteins, Kinases
01
Overview
The cellular mitotic machinery is a complex system of molecular structures and proteins that orchestrate the accurate segregation of chromosomes during cell division (mitosis). The centerpiece of this machinery is the mitotic spindle, a dynamic, microtubule-based structure responsible for capturing, aligning, and separating duplicated chromosomes into two daughter cells. Errors in the mitotic machinery can lead to genetic instability and aneuploidy, which are hallmarks of many cancers, making it an important target for anti-cancer therapeutics.
02
Mechanism of action
Disruption of microtubule dynamics, inhibition of mitotic kinases, inhibition of motor proteins
03
Biological functions
Chromosome segregationCell divisionSpindle assemblyKinetochore attachmentMitosis regulation
04
Disease associations
CancerAneuploidyGenetic instabilityTumorigenesis
05
Safety considerations
Off-target effects due to the involvement of mitotic machinery in normal cell divisionDrug resistance
06
Interacting drugs
Taxol
5 more in the full profile.
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