Cellular Oxidative Stress Pathways

Cellular oxidative stress pathways are a complex network of molecular and biochemical processes that detect, respond to, and mitigate the effects of oxidative stress within cells. These pathways maintain redox homeostasis by regulating ROS levels, activating antioxidant defense mechanisms, and modulating cellular processes such as proliferation, apoptosis, autophagy, migration, and inflammation in response to oxidative cues. Key components include Nrf2, FOXO3a, MAPK pathways, and enzymes like superoxide dismutases, catalases, and glutathione peroxidases. Proper function protects against DNA damage, lipid peroxidation, and protein oxidation, while dysregulation contributes to aging and diseases like cancer or neurodegeneration.

Other names

Oxidative stress response pathwaysROS signaling pathwaysAntioxidant defense mechanisms