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Target intelligence / Profile preview
Cellular Prion Protein (PrPC)
- Target
- PrPC
- Molecular classification
- Glycoprotein, GPI-anchored protein, Cell surface receptor
01
Overview
Cellular prion protein is an essential CNS-expressed GPI-linked glycoprotein involved primarily with metal ion homeostasis, neuroprotection, signal transduction scaffolding—and whose misfolded state underlies fatal transmissible neurodegenerative disorders. PrPC acts as a dynamic cell-surface scaffold protein capable of assembling signaling modules by interacting with various extracellular ligands. This enables modulation of intracellular signaling cascades relevant to neuronal survival and plasticity. Aberrant misfolding of PrPC into PrPSc is the hallmark of prion diseases.
- Other names
- Prion proteinPRNP
02
Mechanism of action
Modulation of PrPC misfolding, prevention of PrPSc formation, inhibition of PrPC-amyloid beta interaction (potential)
03
Biological functions
Copper homeostasisNeuroprotectionSignal transductionCell adhesionStem cell renewalMemory formation
04
Disease associations
Prion diseases (Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, scrapie, chronic wasting disease)Alzheimer's disease
05
Safety considerations
Potential for off-target effects due to broad expressionBlood-brain barrier penetration challenges for therapeutic agents
06
Biomarkers
PrPC levels in cerebrospinal fluid (diagnostic/prognostic for prion diseases)PrPSc detection (diagnostic for prion diseases)
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