Cellular protein involved in DNA repair pathway

"Cellular proteins involved in DNA repair pathways" is not a single molecule or receptor but rather refers collectively to a large and diverse set of **proteins** that detect, signal, and correct various forms of **DNA damage** within the cell. These include enzymes such as nucleases (e.g., XPF), helicases (e.g., WRN), polymerases (e.g., Polζ), scaffold/adaptor proteins (e.g., SLX4), chromatin remodelers, and regulatory kinases. Key examples are **BRCA1**, **BRCA2**, **RAD51**, **PARP1**, components of the MRN complex (**MRE11-RAD50-NBS1**), RPA subunits (**RPA1/2/3**), FANCI/FANCD2 from the Fanconi anemia pathway, among many others[1][3][5]. These proteins function across several distinct but sometimes overlapping pathways including base excision repair, nucleotide excision repair, mismatch repair, homologous recombination repair, non-homologous end joining and direct reversal mechanisms[6][7]. Defects or mutations in these genes/proteins are strongly associated with increased risk for cancer development due to loss of genome integrity. Because this entry refers broadly to an entire functional class rather than a specific molecular entity or druggable target—and includes multiple unrelated families—it is considered *incorrect* as an individual therapeutic target according to standard nomenclature conventions. For structured data purposes it should be replaced by entries for each specific protein/gene involved in particular DNA repair processes. --- If you need information on any *specific* cellular protein within these pathways—such as "Poly(ADP-ribose) polymerase 1" (*PARP1*) or "Breast cancer type 2 susceptibility protein" (*BRCA2*)—please specify which one.

Other names

DNA repair proteinDNA damage response proteinGenome maintenance factor