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Cellular protein metabolic process

Molecular classification
Other
01

Overview

Cellular protein metabolic process" refers to the entirety of biochemical reactions related to the synthesis, modification, and degradation of proteins within cells. This includes the translation of amino acids into polypeptides, post-translational modifications (such as phosphorylation, ubiquitination, methylation, acetylation, glycosylation), and the breakdown of proteins via systems like the ubiquitin-proteasome pathway. These processes are essential for cellular homeostasis, signal transduction, and adaptation to environmental changes. Dysregulation of protein metabolic processes contributes to a wide range of diseases, including cancer, metabolic and neurodegenerative disorders. However, "cellular protein metabolic process" is not a druggable target as such, but rather an umbrella term for numerous enzymatic and regulatory systems involved in protein metabolism[4][5][7]. This entry is classified as incorrect as a molecular drug target because it is not specific—it encompasses many enzymes, transporters, and pathways, rather than a distinct molecular entity or receptor.

Other names
protein metabolismcellular protein metabolismprotein metabolic process
02

Biological functions

Protein synthesis (anabolism)Protein degradation (catabolism, including ubiquitin-proteasome system)Protein modification (post-translational modification: phosphorylation, acetylation, methylation, ubiquitination, glycosylation, etc.)Cellular homeostasisSignal transduction
03

Disease associations

CancerMetabolic disordersNeurodegenerative disease (e.g., aberrant protein turnover)Cardiovascular diseaseOther

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