Cellular proteins and enzymes

The term 'Cellular proteins and enzymes' refers to a broad and non-specific category encompassing the vast majority of functional molecules within a cell. In pharmacology and drug discovery, a therapeutic target is defined as a specific molecular entity, such as a single receptor, enzyme, or ion channel, that can be selectively modulated by a drug to treat a disease (NIH, 2023). This entry is considered incorrect as a target because it represents a general biological class rather than a discrete, druggable molecule. Attempting to target cellular proteins and enzymes as a collective group would lack the necessary selectivity for therapeutic efficacy and would likely result in catastrophic off-target effects and systemic toxicity (IUPHAR, 2024). Consequently, this term is too broad for structured pharmacological data entry or drug development purposes.

Other names

ProteomeIntracellular enzymesCellular proteins

Not applicable for a generic category.