Cellular proteins and extracellular matrix components

Cellular proteins and extracellular matrix (ECM) components encompass a broad array of molecules that constitute the structural and functional framework of tissues. The ECM is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans, elastin, fibronectin, laminins, and several other glycoproteins (Source: NIH, StatPearls). These components provide essential physical scaffolding for cellular constituents and exert profound influence over cell behavior, including adhesion, migration, and differentiation (Source: Journal of Cell Biology). In pathological conditions such as cancer, the ECM is often extensively remodeled, facilitating tumor progression and metastasis, while in fibrotic diseases, excessive accumulation of ECM proteins leads to organ dysfunction (Source: Nature Reviews Molecular Cell Biology). While 'cellular proteins and ECM components' is too broad to be considered a single therapeutic target, many specific constituents within this category are targeted by drugs, such as collagenase for Dupuytren's contracture or integrin antagonists to prevent platelet aggregation (Source: FDA, PubChem).

Other names

Extracellular matrixECMCellular proteomeIntercellular matrix

Enzymatic degradation of matrix proteins, inhibition of matrix synthesis, or blockade of cell-matrix adhesion receptors.