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Target intelligence / Profile preview
Mitochondrial respiration
- Molecular classification
- Metabolic pathway, Enzyme complex
01
Overview
Mitochondrial respiration is the primary process by which cells generate energy in the form of adenosine triphosphate (ATP) through the oxidation of substrates, mainly glucose, fatty acids, and amino acids. This process occurs within mitochondria and is essential for cellular viability and function. It involves oxidative phosphorylation and the citric acid cycle, converting chemical energy into ATP, and is regulated by substrate availability and other factors.
- Other names
- Cellular respirationOxidative phosphorylationElectron transport chainBioenergeticsMitochondria functionEnergy metabolism
02
Mechanism of action
Inhibition of electron transport chain complexes or ATP synthase.
03
Biological functions
ATP synthesisEnergy conversionNutrient oxidationProton gradient generationOxygen consumption
04
Disease associations
Mitochondrial myopathiesNeurodegenerative disordersApoptosisCell deathCancer
05
Safety considerations
Impaired regulation leading to apoptosis or cell deathDefects leading to mitochondrial diseases
06
Interacting drugs
Rotenone
3 more in the full profile.
07
Biomarkers
Oxygen consumption rate (OCR)Basal respiration rateMaximal respiratory capacityProton leakNon-mitochondrial respiration
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