Cellular retinoic acid-binding protein 2 (CRABP2)

Cellular retinoic acid-binding protein 2 (CRABP2) is a small, highly conserved cytosolic protein that binds all-trans retinoic acid (RA), the most active form of vitamin A[1][3][4][5]. Its principal function is to transport RA from the cytoplasm into the nucleus, delivering it to nuclear retinoic acid receptors (RARs) and thereby regulating gene transcription in response to RA signaling[1][3][4]. CRABP2 plays crucial roles in development, especially in tissue-specific cellular differentiation, bone growth, skin homeostasis, and embryogenesis, reflecting RA’s pleiotropic biological activities[1][3][5]. Alterations in CRABP2 expression have been implicated in cancer (including basal cell carcinoma and embryonal carcinoma), accelerated skin aging, and abnormal bone development[1][3][4][5]. As a drug target, CRABP2 is significant for understanding both therapeutic benefit and toxicity of retinoid-based therapies[5].

Other names

Cellular retinoic acid-binding protein IICRABP-IIRBP6CRABP2

Facilitates nuclear import of retinoic acid, enabling RA to bind and activate retinoic acid receptors (RARs), modulating transcription of target genes[1][3][4][5]. Influences cellular differentiation and proliferation by altering RA signaling strength[1][3][5].