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Target intelligence / Profile preview
Cellular Retinoic Acid Binding Protein I (CRABP I)
- Target
- CRABP I
- Molecular classification
- Intracellular lipid-binding protein (iLBP)
01
Overview
Cellular Retinoic Acid Binding Protein I (CRABP I) is a cytoplasmic protein that binds retinoic acid, a metabolite of vitamin A. It plays a crucial role in regulating retinoic acid signaling by modulating its availability to nuclear receptors and influencing cell cycle progression and apoptosis. CRABP I is implicated in development and cancer.
- Other names
- CRABPI
02
Mechanism of action
Modulates retinoic acid availability to nuclear receptors; activates ERK1/ERK2 kinases
03
Biological functions
Retinoic acid transportRegulation of retinoid signalingCell cycle regulationApoptosis regulationStem cell renewal
04
Disease associations
CancerEmbryonic development disorders
05
Safety considerations
Potential for retinoid-induced teratogenesis
06
Interacting drugs
All-trans-retinoic acid
1 more in the full profile.
07
Biomarkers
CRABP1 methylation status (in cancer)
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