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Target intelligence / Profile preview
Cellular Tumor Antigen p53 R175H (p53 R175H)
- Target
- p53 R175H
- Molecular classification
- Transcription factor, Tumor suppressor, Neoantigen
01
Overview
Cellular tumor antigen p53 R175H is a mutant form of the human tumor suppressor protein p53. The R175H mutation results in loss of wild-type tumor-suppressive functions and confers new oncogenic properties, promoting cancer cell proliferation, migration, invasion, and metastasis. It represents a key oncogenic driver and an attractive target for next-generation precision therapies.
- Other names
- Mutant p53-R175HTumor suppressor P53 R175Hp53 R175H mutant
02
Mechanism of action
Small molecules that restore wild-type-like conformation or function; Compounds promoting degradation of stabilized mutant protein; Immunotherapies leveraging presentation of unique neoepitopes for targeted killing by cytotoxic T lymphocytes or bispecific antibody constructs.
03
Biological functions
OncogenesisCell proliferationAngiogenesisMetastasisDrug resistanceTranscriptional regulation
04
Disease associations
CancerBreast cancerLung cancerColorectal cancerPancreatic cancerOsteosarcomaOvarian cancer
05
Safety considerations
Off-target effects of drugs designed to restore wild-type functionPotential for immune-related adverse events with immunotherapiesDevelopment of resistance to targeted therapies
06
Biomarkers
Presence of R175H mutation in TP53 geneExpression level of mutant p53-R175H proteinPresentation of R175H-derived peptides on HLA molecules
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