Cellular Uptake of Thyroid Hormones (TH Uptake)

Cellular uptake of thyroid hormones is the process by which thyroxine (T4) and triiodothyronine (T3) are transported from the bloodstream into target cells via carrier-mediated processes involving specific membrane transporters like MCT8, OATPs, and LATs. This uptake is crucial for maintaining appropriate intracellular hormone concentrations, especially for active T3, and for thyroid hormones to exert their biological effects by interacting with nuclear receptors and regulating gene expression. Impaired transporter function can lead to cellular hypothyroidism, even with normal serum levels, contributing to various conditions like insulin resistance and neurodegenerative diseases. The pituitary gland's unique transporter profile can mask peripheral tissue hypothyroidism in standard serum TSH measurements.

Other names

Thyroid Hormone TransportT4 UptakeT3 UptakeThyroid Hormone Import

Modulation of thyroid hormone transport into cells, influencing intracellular T3/T4 concentrations and downstream effects on gene transcription and metabolism.