Cellulose matrix for hemostasis

Cellulose matrices, especially oxidized regenerated cellulose, are absorbable biomaterials used as topical hemostatic agents. When applied to bleeding sites, they rapidly absorb blood and form a dense physical barrier, accelerating hemostasis primarily through surface-induced platelet activation and aggregation. These matrices serve as a scaffold for clot formation, and their large surface area helps concentrate clotting components at the wound. Some products can also modulate local inflammatory and cellular responses, supporting both hemostasis and post-injury healing. They are commonly used in surgical and trauma settings, especially when traditional hemostatic methods are insufficient or impractical

Other names

Cellulose-based hemostatic agentOxidized cellulose matrixHemostatic cellulose dressingOxidized regenerated cellulose (ORC)

Acts as a physical barrier at bleeding sites by forming a dense matrix which: - Absorbs fluids - Provides a scaffold for platelet adhesion/aggregation - Concentrates clotting factors and platelets - Triggers clotting via surface-induced activation of the coagulation cascade (can activate factor XII, influencing the intrinsic pathway) - Modulates local cellular responses supporting hemostasis and healing