Central dopaminergic tone

Central dopaminergic tone" refers to the **baseline level of extracellular dopamine** present in the central nervous system, particularly in brain regions such as the striatum and cortex. This tonic level is maintained by a balance between **dopamine neuron firing rates** and **dopamine reuptake via the dopamine active transporter (DAT)**. The concept describes a physiological state rather than a discrete molecular entity or receptor. Variations in central dopaminergic tone influence numerous functions including movement automatization, reward learning, arousal states, and are implicated in various neuropsychiatric and movement disorders[1]. It is not itself a therapeutic target but rather an emergent property of multiple interacting components within the dopaminergic system.

Other names

Central dopamine toneDopaminergic toneTonic dopamine signalingBasal dopaminergic activity