Central Nervous System Adenosine Receptor (CNS Adenosine Receptor)

Adenosine receptors in the central nervous system (CNS) are a family of G protein-coupled receptors (GPCRs) that mediate the physiological and pharmacological effects of adenosine, a purine nucleoside involved in neuromodulation. These receptors play crucial roles in regulating neurotransmitter release, neuronal excitability, synaptic plasticity, and neuroprotection. There are four known subtypes: A1, A2A, A2B, and A3. The most prominent subtypes in the CNS are A1 and A2A. Selective ligands targeting these receptors are under clinical investigation or development for neurological diseases due to their broad regulatory roles within neural circuits.

Other names

Adenosine receptors (CNS)CNS Adenosine ReceptorsPurinergic P1 receptors (CNS)

Modulation of cAMP levels via G protein signaling; alteration of neuronal excitability through ion channel modulation; regulation of neurotransmitter release