Centromere protein F (CENPF)

Centromere protein F (CENPF) is a large nuclear matrix protein critical for correct chromosome segregation during mitosis[1][2][6]. It localizes to the kinetochore in late G2 and maintains association through early anaphase, then relocates to the spindle midzone and intercellular bridge before degradation[1][2][6]. CENPF is essential for the assembly and function of the kinetochore complex and proper orientation of microtubules, influencing both cell division and the formation of cellular cilia[1][2]. Mutations in CENPF disrupt cell division and ciliogenesis, causing developmental disorders such as Strømme syndrome[1][2]. Autoantibodies to CENPF are observed in some cancers and graft-versus-host disease[1][2]. CENPF's pivotal role in mitosis and cell proliferation has stimulated interest as a potential therapeutic target in oncology, but no clinically approved drugs are currently directed at CENPF[5].

Other names

CENPFCENP-Fmitosinhcp-1AH antigenKinetochore protein CENPFCENFCILD31PRO1779STROMSLEK1

Not applicable; no approved drugs directly modulate CENPF. Hypothetically: Cell cycle inhibition, disruption of kinetochore-microtubule interactions, mitotic blockade