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Target intelligence / Profile preview
Centromere protein K (CENPK)
- Target
- CENPK
- Molecular classification
- Other (Component of the centromeric complex; not a receptor, enzyme, or transporter)
01
Overview
Centromere protein K (CENPK) is a protein component of the centromeric complex, required for the assembly and function of the kinetochore, which attaches spindle microtubules to chromosomes during mitosis. Through coordinating with other centromeric proteins, CENPK ensures accurate chromosome segregation, mitotic progression, and cell proliferation. Dysregulation or overexpression of CENPK is linked to carcinogenesis in various cancers, and knockout models have shown that its loss leads to cell-cycle arrest and cell death, emphasizing its critical cellular role[1][3][4].
- Other names
- Centromere protein KCENPKICEN37FKSG14CENP-KSOLTInterphase centromere complex protein 37Protein AF-5alphap33AF5alphaSoxLZ/Sox6-binding protein Soltleucine zipper protein FKSG14[3]
02
Biological functions
Chromosome segregationKinetochore assemblyMitotic progressionCell cycleCell proliferation
03
Disease associations
Cancer (notably ovarian cancer, triple-negative breast cancer, lung cancer, hepatocarcinoma, prostate cancer)
04
Safety considerations
Possible therapeutic challenge due to its essential role in normal cell cycle and chromosome segregation
05
Biomarkers
Potential biomarker for cancer progression and prognosis, especially in prostate cancer
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