Centromere protein L (CENPL)

Centromere protein L is a subunit of the centromeric complex required for accurate chromosome segregation during mitosis and meiosis[4]. It functions as part of the CENPH-CENPI-associated network and assists in recruiting centromere protein A (CENPA) to centromeres, which is fundamental for proper kinetochore assembly and mitotic progression. CENPL is directly involved in essential biological processes including the cell cycle, DNA replication, chromosome segregation, DNA repair, and cellular proliferation[2][4]. Increased expression of CENPL is associated with several cancers, including breast cancer and lung adenocarcinoma, where it serves as a diagnostic and prognostic biomarker and correlates with poorer prognosis[2][6]. CENPL depletion leads to cell cycle arrest and apoptosis in cancer cell models, underscoring its importance in cell proliferation. It also appears to influence immune cell infiltration in tumors, showing a negative association with CD8+ T-cell levels and suggesting a potential role in the tumor microenvironment[2]. Currently, CENPL is not known to be the direct molecular target of any approved drug, nor are its mechanisms of drug interaction characterized.

Other names

CENPLC1orf155ICEN33CENP-LdJ383J4.3FLJ31044Interphase centromere complex protein 33